原标题：出国

1. Good afternoon, my respectiveprofessors, it is my honor to participate in this Grant Application for StudyAbroad.
2. My presentation is as following: my CVs,my clinical work, Scientific Research, peer exchange, my research content andthe plan of study aboard.
3. My name is Wu Qichao, thirty threeyears old, come from Shandong Province，MD/Ph.D. I am a member of CAA, a resident of Fudan Universityshanghai Cancer Centre. I passed the CET6 exam in 2010.
4. I received my master's degree fromQingdao University. My mentor is Professor Chu Haichen. I became a Ph.D.inFudan University under the guidance of Professor Miao Changhong.
5. For clinical work, I completed thestandardized training of resident doctors, obtained the Medical practitioner's QualificationCertificate and Attending Doctor's Certificate. I am always interested in newanesthesia techniques, such as ultrasound-guided nerve block and TEE.
6. In scientific research, I havepublished 10 SCI articles.
7. eight out of the 10 as the first authorwith a total score of 27 and a maximum score of 5.95. I will introduce them indetail later.
8. At the same time, it is very lucky forme to receive funding from the National Natural Science Foundation of China, Whichfocus on the relationship between metabolism and ROS production of EC cellsduring the perioperative period.
9. 9. As a member of CAA, I participated invarious peer exchanges actively. I won the first prize of Shanghai Science andTechnology as a participant, participated in the Fast-track anesthesia speechcontest, the China Oncology Conference, and the National Anesthesia AnnualMeeting.
10. 10. In addition to participating in thecompetition, I also served as a volunteer at various anesthesia conferences. Ihave been a volunteer for OCAP for four years.
11. 11. Then Let me introduce my researchcontent below. My research is about the relationship between perioperativemanagement and tumor prognosis. When comes to this topic, there will be threequestions:Why does perioperative intervention promote tumor metastasis? Whatcan anesthesiologists do about the outcome of the tumor? How doanesthesiologists promote the long-term prognosis of cancer?
12. 12. The first question, perioperativetrauma can promote tumor postoperative metastasis in many ways, however, theyall land on two kinds of cells. Circulating tumor cells and tumor-associatedvascular endothelial cells. Surgical trauma increases the number of CTCs, andTEC allows the CTC to metastasize distantly. So my research object is one of thetwo: TECs.
13. 13. What have we always done with cancerpatients during the anesthesia? Inanesthesia, a patient has lower blood pressure, lower heart rate, and lowerbody temperature, which all indict a lower basal metabolic rate.
14. 14. Meanwhile, deregulating energetics isone of the ten characteristics of tumor cells. The Warburg effect, also knownas aerobic glycolysis, is not only one of the classic features of tumor cells,but also an emerging target of tumor therapy.
15. 15. I found that Anesthetics includingpropofol and nalmefene, inhibiting tumor cells by disrupting the Warburgeffect.
16. 16. In fact, not only tumor cells, TEC andnormal EC are also very different in metabolism. Enhanced aerobic glycolysis is the maindifferences between TECs and NECs, and the main driving reason for TECs.
17. 17. I found that propofol can inhibit theWarburg effect, reduce ROS production, and promote the normalization of TECs,which may improve the prognosis of the tumor.
18. 18. The last question, we all know thatanesthesia is a reversible process, which may be as short as half of an hour,then would anesthesia affect the long-term prognosis of the tumor? In fact,short-term metabolic changes can affect tumor epigenetics. Epigenetic are genetic changes that can beinherited while without Any changes in DNA sequences.
19. 19. Therefore, my current research is theeffect of anesthesia on the epigenetic effects of TEC cells by regulating theWarburg effect. I found that methylated protein SET8 can regulate aerobicglycolysis in liver cancer.
20. 20. However, there are so many metabolismways in TECs and so many forms of epigenetics. Besides experimental research,only bioinformatics analysis can tell us the interplay between metabolomics andepigenetics in TECs during the Perioperative period.
21. 21. Therefore, I plan to learnbioinformatics technology while continuing scientific research during studyingoversea. I hope I can apply the big data analysis methods to scientificresearch and publish one to three articles abroad.
22. 22. As a young man, I have a long way to goon both clinical work and scientific research. I will always be on the road oflearning. On this road, I can't go on without the support of you, my respectiveprofessors. thank you all very much!

责任编辑：